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KMID : 0363619970180010337
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Journal of Korean Oriental Medicine
1997 Volume.18 No. 1 p.337 ~ p.343
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A study on cerebral ischemic model of rat (Effect of 1 hour occlusion of CCA on the distal or proximal MCA occlusioned site)
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Yoon Sang-Hyub
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Abstract
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With the purpose of producing easily the basal ganglia infarction into Chen’’s, scerebral ischemic model which is almost cortical infarct made by the ligation of distal part of MCA and 1 hr obliteration of both common carotid arteries in rat, the MCA obstruction was extended between rhinal fissure and olfactory tract with electrocauterization in place of 10-0 silk suture ligation of distal part of MCA. Both original Chen’’s model and modified Chen’’s have shown the cortical infarction in dorsolateral & lateral frontoparietal cortex, but not any infarction in basal ganglia. However, the modified Chen’’s model have shown the effect of average 12% increase in cortical infarct than that of original Chen’’s model. This experimental results suggest the modified Chen’’s model can not reduce the blood flow of the lateral lenticulostriatal artery enough to make the basal ganglia infarction and that blood circulation of basal gagglia under its condition is probably being kept partly through the posterior cerebral artery via vertebral artery. Therefore, The follow-up observation on ischemic time lapse would be needed.
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KEYWORD
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animal model, cerebral ischemia, rat
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